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目的:观察冠状动脉成形术加支架植入术治疗对冠心病血瘀讧的影响。方法:观察60例冠心病冠状动脉成形术加支架植入术(PTCA+STENT)治疗前后血瘀证评分和血瘀证相关的实验室指标(TXB_2、6-keto- PGF_(1α)、ET、NO)的变化。结果:PTCA+STENT治疗冠心病后7天、30天较治疗前血瘀证积分、及相关实验室指标(TXB_2、6-keto-PGF_(1α)、ET)均明显降低(P<0.05),而NO则较治疗前明显上升(P<0.05);PTCA+STENT治疗冠心病后30天与治疗后7天血瘀证积分比较,差异有显著性意义(P<0.05);PTCA+STENT治疗冠心病后30天较治疗后7天TXB_2、6-keto-PGF_(1α)、ET升高(P<0.05),而NO则无明显差异(P>0.05)。结论:PTCA+ STENT治疗在短期时间能明显改善冠心病血瘀证表现,但长时间有潜在引起再次发生或加重血瘀证的可能。
Objective: To observe the effect of coronary angioplasty and stent implantation on blood stasis syndrome of coronary heart disease. Methods: Sixty patients with coronary heart disease undergoing coronary angioplasty plus stent implantation (PTCA + STENT) before and after treatment were assessed for blood stasis score and laboratory markers related to blood stasis (TXB 2, 6-keto- PGF 1α, ET, NO) changes. Results: The scores of blood stasis syndrome and related laboratory parameters (TXB2, 6-keto-PGF1α, ET) in PTCA + STENT group were significantly lower than those before treatment (P <0.05) While NO was significantly higher than that before treatment (P <0.05). There was significant difference between the scores of 30 days after PTCA + STENT and 7 days after PTCA + STENT (P <0.05) The levels of TXB_2, 6-keto-PGF_ (1α) and ET increased 30 days after cardiopulmonary disease compared with 7 days after treatment (P <0.05), while there was no significant difference between the two groups (P> 0.05). Conclusion: PTCA + STENT treatment can significantly improve the performance of blood stasis syndrome in short-term, but may lead to the recurrence or aggravation of blood stasis for a long time.