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目的观察纳洛酮联合复方脑肽节苷脂治疗重度颅脑损伤的临床疗效。方法将医院收治的84例重度颅脑损伤患者随机分为对照组和观察组,每组42例。对照组在常规治疗基础上加用纳洛酮治疗,观察组在对照组治疗基础上联合应用复方脑肽节苷脂治疗,疗程均为1个月。观察2组患者临床效果、神志转清时间及治疗前后格拉斯哥评分(GCS)变化。结果治疗后,2组GCS评分均高于治疗前,观察组治疗后GCS评分高于对照组(P均<0.05)。观察组神志转清时间为(10.95±2.28)d,短于对照组的(16.25±3.15)d(P<0.05)。观察组治疗后总有效率为92.86%,高于对照组的71.43%(P<0.05)。结论纳洛酮联合复方脑肽节苷脂治疗重度颅脑损伤的临床疗效显著,可明显改善患者的神志状况,值得临床推广应用。
Objective To observe the clinical efficacy of naloxone combined with compound brain stem ganglioside in the treatment of severe craniocerebral injury. Methods Eighty-four patients with severe traumatic brain injury admitted to hospital were randomly divided into control group and observation group, with 42 cases in each group. The control group was treated with naloxone on the basis of conventional treatment. The observation group was treated with compound brain peptide ganglioside on the basis of the control group, and the course of treatment was 1 month. The clinical effects, the time of conscious mind clearance and the changes of Glasgow score (GCS) before and after treatment were observed in two groups. Results After treatment, GCS scores of two groups were higher than those before treatment, GCS score of observation group was higher than that of control group (all P <0.05). The conscious time of the observation group was (10.95 ± 2.28) d, which was shorter than that of the control group (16.25 ± 3.15) d (P <0.05). The total effective rate of the observation group after treatment was 92.86%, which was higher than that of the control group (71.43%, P <0.05). Conclusion Naloxone combined with compound brain peptide ganglioside treatment of severe traumatic brain injury has a significant clinical effect, which can significantly improve the patient’s mental status, worthy of clinical application.