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目的 :探讨儿童型系统性红斑狼疮 (SLE)的临床特点及治疗经验。方法 :采取回顾性研究方法分析儿童型系统性红斑狼疮的临床特点和治疗疗效 ,并与中青年组SLE相比较。结果 :儿童型狼疮的首发症状中 ,发热、雷诺氏现象、淋巴结肿大以及肝脾肿大的发生率显著高于中青年组 ,免疫学检查Ads -DNA阳性多见 ,并伴有高丙球蛋白血症 ,发生率明显高于中青年组 (P <0 .0 5 )。治疗根据病情活动和脏器累及决定治疗方案 ,可取得良好效果。结论 :儿童型狼疮发病不典型 ,易误诊。我国 1982年 3月SLE诊断标准较美国风湿病学会标准更有利于儿童型狼疮的早期诊断 ,依疾病活动及脏器累及制订治疗方案 ,可取得良好效果。
Objective: To investigate the clinical features and treatment experience of children with systemic lupus erythematosus (SLE). Methods: A retrospective study was carried out to analyze the clinical features and therapeutic efficacy of children with systemic lupus erythematosus (SLE) and compared with SLE in middle-aged and young adults. Results: The incidence of fever, Raynaud’s phenomenon, lymphadenopathy and hepatosplenomegaly were significantly higher in the first symptom of childhood lupus than in young and middle-aged patients. Ads-DNA was more common in immunological examination and was associated with hypergammaglobulinemia Symptoms, the incidence was significantly higher than the young group (P <0. 05). Treatment based on disease activity and organ involvement involving treatment decisions, can achieve good results. Conclusion: The onset of childhood lupus is not typical and is easily misdiagnosed. China March 1982 SLE diagnostic criteria more than the American College of Rheumatology standard is more conducive to the early diagnosis of children with type lupus, according to disease activity and organs involved in the development of treatment options, can achieve good results.