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目的总结卵巢高级别浆液性癌在宫颈液基细胞学中的临床细胞病理学特征。方法回顾性总结2013年5月至2016年3月首都医科大学附属北京妇产医院病理科宫颈液基细胞学诊断为非典型腺细胞及以上病变、组织病理学诊断为卵巢高级别浆液性癌的9例病例的临床资料以及细胞病理学特点。结果 9例中宫颈细胞学诊断腺癌7例,非典型腺细胞倾向瘤变2例。原发病例的细胞涂片特征为:干净的背景中可见异型显著的三维立体细胞团,细胞活跃,核/浆比增大,可见明显的核仁,染色质增粗,部分细胞浆内可见空泡样改变。而阴道残端复发病例中可见肿瘤素质及较多散在异型明显的腺细胞。结论卵巢高级别浆液性癌在宫颈液基细胞学中有其征性细胞学特点。原发病例宫颈细胞学阳性者均伴有腹水,提示患者卵巢高级别浆液性癌进展至晚期。宫颈液基细胞学是发现卵巢高级别浆液性癌的途径之一,更是肿瘤术后随访、发现残端复发的有效方法。
Objective To summarize the clinical cytopathological features of high grade serous ovarian carcinoma in cervical liquid-based cytology. Methods The retrospective summary of cervical cytology-based cytology diagnosed as atypical glandular cells and above lesions in Beijing Maternity Hospital Affiliated to Capital Medical University from May 2013 to March 2016 was diagnosed as high grade serous carcinoma of the ovary by 9 Cases of clinical data and cytopathological features. Results In 9 cases, cervical cytology diagnosed adenocarcinoma in 7 cases and atypical glandular cell carcinoma in 2 cases. The characteristics of the primary smear smears were as follows: a clear three-dimensional cell mass with obvious shape was seen in a clean background, the cells were active, the nucleus / pulp ratio increased, and the obvious nucleoli were visible; the chromatin was thick and part of the cytoplasm was empty Bubble change. The recurrence of vaginal stump can be seen in the tumor quality and more scattered abnormally shaped gland cells. Conclusions High grade serous ovarian cancer has its characteristic cytology in cervical liquid-based cytology. Primary cases of cervical cytology are associated with ascites, suggesting that patients with advanced ovarian serous advanced to advanced stages. Cervical liquid-based cytology is one of the ways to find high-grade serous ovarian cancer, but also follow-up of the tumor and found an effective method of stump recurrence.