目的:抗溃结复发方对UC模型大鼠结肠黏膜形态的影响。方法:用三硝基苯磺酸(TNBS)复制实验性大鼠UC模型,将其随机分为模型组、西药对照组、中药治疗组,并设正常对照组。结果:两治疗组急性期损伤减轻,但中药治疗组与西药组相比表现为重;中期、缓解期慢性炎性细胞浸润和腺体破坏减轻,中药治疗组修复加快优于西药组。结论:中西药物对局部黏膜均有抑制炎症反应和促进组织修复作用;在急性期西药抑制损伤方面优于中药,在中期和缓解期促进肉芽组织增生修复方面中药优于西药。 Objective: To study the effect of Kangluo Recipe on colonic mucosal morphology in rats with UC. Methods: Experimental rat model of UC was duplicated with trinitrobenzene sulfonic acid (TNBS) and randomly divided into model group, western medicine control group and traditional Chinese medicine treatment group and normal control group. Results: The acute phase injury of both treatment groups was alleviated, but the Chinese medicine treatment group was more severe than the western medicine group. The chronic inflammatory cell infiltration and gland destruction were relieved in the mid-term and remission periods. The Chinese medicine treatment group was faster than the Western medicine group. Conclusion: Both Chinese and western medicine can inhibit inflammation and promote tissue repair in local mucosa. It is superior to traditional Chinese medicine in inhibiting acute injury in acute stage and promoting the proliferation of granulation tissue in mid and remission stage.