目的介绍微电极导向同期双侧腹后苍白球毁损术治疗帕金森病的方法与效果.方法应用微电极电生理记录技术术对毁损靶点进行确认定位,对31例难治性帕金森病患者行同期双侧腹后内侧苍白球毁损治疗,术前及术后于开状态、关状态分别行改良WEBSTER记分,计算改善率,评价其疗效.结果经微电极确认后的电生理靶点与CT定位靶点存在明显差异,靶点调整率80?6％.31例手术均有效,其中治愈7例,明显进步24例.WEBSTER计分术后1周开状态改善率为74?2％±9?5％,关状态改善率为89?1％±8?9％.无永久性并发症.结论微电极导向同期双侧腹后苍白球毁损术安全、有效,具有明显临床治疗优势,微电极记录技术可使术中定位精确度大大提高.“,”Objective To introduce the methods and effects of microelectrode guided contemporaneous bilateral posteroventral pallidotomy (BPVP) for Parkinson’’s disease. Methods 31 patients underwent contemporaneous BPVP by means of microelectrode electrophysiolgical recording used as intraoperative target localizations.Webster scale modified was used for preoperative and postoperative clinical assessments.Postoperative CT scan was performed to ensure the lesion posi...