目的观察糖尿病大鼠肺组织β2肾上腺素能受体mRNA表达的变化。方法28只大鼠随机分为正常组和糖尿病组(腹腔注射链脲佐菌素建模)。采用实时荧光定量PCR检测肺组织β2肾上腺素能受体mRNA的表达,并进行比较。结果与正常大鼠比较,糖尿病组大鼠肺组织的β2受体mRNA的表达下调(P<0.01)。结论糖尿病大鼠肺组织β2受体mRNA的表达下降,可能是糖尿病肺功能受损的发病基础。 Objective To observe the changes of β2 adrenergic receptor mRNA expression in the lung tissue of diabetic rats. Methods Twenty-eight rats were randomly divided into normal group and diabetic group (intraperitoneal injection of streptozotocin model). The expression of β2 adrenergic receptor mRNA in lung tissue was detected by real-time fluorescence quantitative PCR and compared. Results Compared with normal rats, the expression of β2 receptor mRNA in lung tissues of diabetic rats was down-regulated (P <0.01). Conclusion The decreased expression of β2 receptor mRNA in lung tissue of diabetic rats may be the basis of the pathogenesis of diabetic pulmonary function impairment.