Objective: To explore the characteristics of bone mineral density (BMD) and treatment in Chinese patients with complete androgen insensitivity syndrome (CAIS).Methods: Fourteen cases of CAIS were studied retrospectively through analyzing and comparing BMD of pre-and post-gonadectomy with healthy Chinese men and women. BMD at the lumbar spine and the femur were measured by dual energy X-ray absorptiometry (DXA). Results: There were 10 cases of CAIS having pre-gonadectomy DXA, in which 6 cases had very significantly reduced lumbar 2-4 BMD [(0.92±0.08) g/cm2] comparing with both healthy men and women (P＜0.01), 5 cases had significantly reduced femur neck BMD [(0.89±0.12) g/cm2] comparing with healthy men (P＜0.05). There were 7 cases having 12 post-gonadectomy DXA, in which all lumbar 2-4 BMD [(0.95±0.06) g/cm2] were reduced very significantly comparing with both healthy men and women (P＜0.01), femur neck BMD [(0.91±0.08) g/cm2] were also reduced significantly comparing with healthy men (P＜0.01) and women (P＜0.05). Conclusion: There were different degrees of osteopenia in patients of CAIS, especially in lumbar vertebra. This suggests that both estrogen and androgen play important roles in the acquirement and maintenance of peak bone mass.