论文部分内容阅读
目的比较盐酸戊乙奎醚注射液与阿托品治疗急性有机磷农药中毒的疗效。方法选取2011年2月—2015年4月榕江县人民医院收治的急性有机磷农药中毒患者60例,按随机数字表法分为A组与B组,各30例。两组患者入院后均予以常规对症治疗,A组患者予以盐酸戊乙奎醚注射液治疗,B组患者予以阿托品治疗。观察两组患者乙酰胆碱酯酶恢复时间、临床疗效及药物不良反应发生情况。结果 A组患者乙酰胆碱酯酶恢复时间短于B组,总有效率高于B组,不良反应发生率低于B组,差异有统计学意义(P<0.05)。结论盐酸戊乙奎醚注射液治疗急性有机磷农药中毒的临床疗效好于阿托品,可缩短乙酰胆碱酯酶恢复时间,且不良反应少,安全性高。
Objective To compare the efficacy of penehyclidine hydrochloride injection and atropine in the treatment of acute organophosphorus pesticide poisoning. Methods Sixty patients with acute organophosphorus pesticide poisoning admitted from Rongjiang County People’s Hospital from February 2011 to April 2015 were randomly divided into group A and group B, 30 cases in each group. Both groups were given symptomatic treatment after admission, patients in group A were given penehyclidine hydrochloride injection, and patients in group B were treated with atropine. Observed two groups of patients with acetylcholinesterase recovery time, clinical efficacy and adverse drug reactions. Results The recovery time of acetylcholinesterase in group A was shorter than that in group B, the total effective rate was higher than that in group B, and the incidence of adverse reactions was lower than that in group B (P <0.05). Conclusion Penehyclidine hydrochloride injection is superior to atropine in the treatment of acute organophosphorus pesticide poisoning, which can shorten the recovery time of acetylcholinesterase and has less adverse reactions and high safety.