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采用ＴＢＡ荧光法测定ＬＰＯ水平，通过ＨＥ染色，显微镜下观察淋巴结内有无瘤细胞转移，以６１５小鼠作为观察对象，对小鼠肝癌不同转移力瘤株宿主免疫原性与淋巴结转移及淋巴样器官过氧化状态的关系进行探讨。结果显示，高转移组瘤细胞的转移潜伏期较短，其免疫原性较低，宿主免疫反应较低转移组弱而不规律；而淋巴样器官ＬＰＯ的变化特点是：ＬＰＯ上升的２次高峰出现在肿瘤生长潜伏期末及转移潜伏期末。这些结果提示肿瘤的发展及其转移与瘤细胞的免疫原性及宿主淋巴样器官中过氧化反应的亢进密切相关。过氧化反应与免疫功能的关系值得深入研究。
The LPO level was measured by TBA fluorescence method. The metastasis of tumor cells in the lymph nodes was observed by HE staining under microscope and 615 mice were used as the observation object. The immunogenicity, lymph node metastasis, and lymphoid metastasis were observed in different metastatic tumor strains of mouse hepatocellular carcinoma. The relationship between organ peroxidation status is discussed. The results showed that the metastasis latency of the tumor cells in the high metastatic group was shorter, their immunogenicity was lower, and the host immune response was lower; the metastatic group was weak and irregular; whereas the change of the lymphoid organ LPO was characterized by two peaks of LPO rise. At the end of the tumor growth latency and the end of the transfer latency. These results suggest that the development and metastasis of tumors are closely related to the immunogenicity of tumor cells and hyper-peroxidation in host lymphoid organs. The relationship between peroxidation and immune function deserves further study.