论文部分内容阅读
目的进一步认识宫颈腺样基底细胞癌的病理形态及临床特点。方法应用细胞学、组织病理学、免疫组化等方法对1例宫颈腺样基底细胞癌进行分析,并结合相关文献讨论。结果液基涂片细胞学显示有异型的鳞状上皮细胞,符合高级别鳞状上皮内病变的形态学改变。光学显微镜下观察发现,宫颈鳞状上皮下方的间质内有圆形至卵圆形的小细胞巢,部分癌细胞巢的中央出现鳞状分化,周围呈栅栏状结构;肿瘤细胞巢与表面CIN3融合。免疫组化显示p63、p16和CK5/6(+),Ki-67灶状(+);宫颈间质内的部分血管平滑肌及纤维母细胞actin(+),而在癌巢周围呈(-)。结论宫颈腺样基底细胞癌罕见,具有独特的组织病理学特点。宫颈间质内的瘤组织易误认为鳞状上皮化生或被认为CIN累腺。诊断宫颈腺样基底细胞癌,须掌握严格的诊断标准,以作出正确诊断。
Objective To further understand the pathological features and clinical features of cervical adenoid-like basal cell carcinoma. Methods One case of cervical adenoid basal cell carcinoma was analyzed by cytology, histopathology and immunohistochemistry, and the related literatures were discussed. Results Liquid-based smear cytology showed abnormal squamous epithelial cells, in line with high-grade morphological changes of squamous intraepithelial lesions. Under the light microscope, we found that there are round to oval small cell nests in the interstitial below the squamous cervical epithelium, some squamous dendrites appear in the center of the nests of the cancer cells, and the surrounding is palisade-like structure. The nests of the tumor cells and the surface CIN3 Fusion. Immunohistochemistry showed that p63, p16 and CK5 / 6 (+), Ki-67 foci (+); part of vascular smooth muscle and fibroblast actin (+ . Conclusions Cervical adenoid basal cell carcinoma is rare and has unique histopathological features. Cervical stromal tumor tissue easily mistaken for squamous metaplasia or CIN was considered tired. Diagnosis of cervical adenoid basal cell carcinoma, to master the strict diagnostic criteria to make the correct diagnosis.