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采用小牛血清、自体血清及生理盐水作为抗原行内耳继发免疫的实验研究,以听性脑干反应、血清及外淋巴液中的特异性IgG为指标,结果发现牛血清组、自体血清组的耳蜗接种耳听阈提高,牛血清组血清、外淋巴液特异性IgG,抗原注射前后明显增加。提示:①用免疫方法可造成家兔耳聋;②听力损伤机理有体液免疫参与;③内耳对抗原刺激能产生抗体反应,④血清及迷路的IgG平衡存在着血迷路屏障。
Using bovine serum, autologous serum and saline as antigens in the ear secondary to experimental studies of the ear to auditory brainstem response, serum and peripheral lymph of specific IgG as an indicator, found that bovine serum group, autologous serum group The ear threshold of cochlear inoculation increased, serum of bovine serum and extralymphatic fluid specific IgG increased significantly before and after antigen injection. Tip: ① immunization methods can cause deafness in rabbits; ② mechanism of hearing impairment humoral immune involvement; ③ inner ear stimulation of the antigen can produce antibody reactions; ④ serum and lost the balance of IgG there is a blood labyrinth barrier.