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某些病理和生理因素可引起机体一些组织和器官的结构和功能改变,因而影响药物在血浆、组织、靶器官的浓度以及在体内的停留时间,表现为药物作用强度和作用时间的改变。一、低白蛋白血症对药物作用的影响低白蛋白血症对药物作用的影响主要表现为:血浆游离药物浓度升高、药理作用增强,毒副作用可能增加。药物多数在体内和血浆白蛋白不同程度地结合。且暂时失去药理活性。而未被结合呈游离状态的药物才具有活性,游离的药物也更易到达作用的组织
Some pathophysiological and physiological factors can cause changes in the structure and function of some tissues and organs in the body, thus affecting the concentration of drugs in the plasma, tissues, target organs and in vivo residence time, manifested as changes in the intensity of drug action and duration of action. First, the hypoalbuminemia on the impact of drugs Hypoalbuminemia on the role of drugs mainly as follows: the plasma concentration of free drugs, pharmacological effects, toxic side effects may increase. Most drugs in the body and plasma albumin to varying degrees. And temporary loss of pharmacological activity. Drugs that are not bound are active, free drugs are also more accessible to the affected tissue