1病历摘要男,52岁。乙肝肝硬化失代偿期并腹水。入院后予以保肝利尿对症处理。在输注硫普罗宁针约5 min时,患者突然出现双侧下颌肿胀不适,并迅速增大至约小鸡蛋大小,并觉气喘不适,遂即停用硫普罗宁,并冲管,更换液体,静脉推注地塞米松针10 mg,约10 min左右,患者下颌肿块消失,症状缓解。追问病史患者无药物过敏史。2讨论硫普罗宁是一种含游离巯基的 1 medical record summary male, 52 years old. Hepatic cirrhosis decompensated and ascites. After admission to liver protection and diuretic symptomatic treatment. In the infusion of tiopronin for about 5 min, the patient suddenly appeared bilateral mandibular swelling and discomfort, and rapidly increased to about the size of small eggs, and feel asthma discomfort, then stop the use of tiopronin and red tube, replace the liquid , Intravenous injection of dexamethasone needle 10 mg, about 10 min or so, the patient disappeared mandibular mass, symptoms relieved. History of patients asked no history of drug allergy. 2 discussion Tiopronin is a containing free thiol