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用大白鼠250只,雌雄不拘,随机分为对照组,假手术组,病理组,古方组,肝胆通组。每组50只,后三组均采用肝门处双重结扎胆总管造成梗阻性黄疸模型。结果:病理组的肝功能有明显损害,肝细胞和肝组织结构有明显的病理改变,应用古方组及肝胆通组的两组,肝功能得以早期恢复,肝细胞和肝组织结构受到明显的保护,其中肝胆通组明显优于古方组。并对肝胆通的作用机理和梗阻性黄疸手术前后处理的有关问题进行了讨论。
250 rats were randomly divided into control group, sham operation group, pathological group, ancient group, and hepatobiliary group. In each group, 50 rats were used, and the latter three groups used a double ligation of common bile duct at the hilum to create an obstructive jaundice model. RESULTS: Liver function in the pathological group was significantly impaired, and the pathological changes in the structure of hepatocytes and liver tissues were obvious. In the two groups of the ancient group and the hepatobiliary group, the liver function was restored early, and the structure of the liver cells and liver tissues was obviously protected. Among them, the Hepatobiliary group was significantly superior to the ancient group. In addition, the mechanism of hepatobiliary and the related problems before and after operation of obstructive jaundice were discussed.