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目的用A型肉毒杆菌毒素(BTXA)治疗先天性眼球震颤,探求有效治疗方法.方法62例病人治疗前后行肌电图,眼震图.头位扭转角及视力等对比检查.在肌电图监护下,将A型肉毒杆菌毒素注入被选定的眼外肌内,23例手术病人为对照组.结果BTXA治疗前后疗效对比、肌电图,眼震图,头位扭转角及视力差别极显著(P＜0.001).与手术对照组对比无显著性差异(P＞0.05).基本治愈率83.87％,总有效率91.93％.结论A型肉毒杆菌毒素可作为治疗先天性眼球震颤的一种简便、经济、安全、有效的非手术疗法.“,”bjecfive Congenital nystagmas was treated withbotulinum toxin A (BTXA ) with favourable results.Methods A comparison study on the electromyogram.the electronystagographs, the status of the head tor-sion. and the vision was carried out before and after thetreatment. Monitored by electromyography, some bo-tulinum toxin A was injected into the selected extrocularmuscle. The contrast group included twenty -- three sur-gical patients. Results there were prominent differtnceson visual acuity, EMG, ENG, and the status of headtorsion before and after BTXA treatment (P 0. 05 ). In siXty -- two patients foe basic cure rate was83. 87 %, and the total effectiveness was 91. 93 %.Con-clusion botulinum roxin A exotoxin may be a simple. e-conomical. safe, and has pronen to be effective for con-genital mystagmus.