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早已知道胸腺是T 细胞个体发育的重要部位,但调节胸腺细胞增殖和分化的机制至今仍了解很少,近来的研究表明有一小群胸腺细胞具有胸腺内干细胞的性质,这些未成熟的细胞表面无T 细胞分化的标志,为Lyt-2~-/L_3T_4~-(2~-4~-),是胚胎胸腺中最早出现的淋巴样细胞,可分化成表型为Lyt-2~+或L_3T_4~+的成熟的胸腺细胞。已发现这些细胞能够表达IL-1和IL-2受体并与它们发生反应。新近又证明IL-4也有刺激2~-4~-细胞增殖的能力。本文重点研究了IL-4对未成熟2~-4~-
It has been known for a long time that the thymus is an important site for the development of T cells. However, the mechanisms regulating the proliferation and differentiation of thymocytes are still poorly understood. Recent studies have shown that a small group of thymocytes have the property of thymus stem cells, and these immature cells have no surface Lyt-2 ~ - / L_3T_4 ~ - (2 ~ -4 ~ -) is the earliest lymphoid cells in the embryonic thymus and can differentiate into Lyt-2 ~ + or L_3T_4 ~ + Of mature thymocytes. These cells have been found to express IL-1 and IL-2 receptors and react with them. Recently, IL-4 has also been shown to stimulate 2 ~ -4 ~ - cell proliferation. This article focuses on the IL-4 on immature 2 ~ -4 ~