目的　分析附着点炎相关关节炎 (ERA)的临床特征。方法　 2 0 0 2年 8～ 11月共收治12例ERA ,全部符合ILAR关于幼年特发性关节炎 (JIA)和ERA的分类标准。对性别、年龄、家族史、临床表现、影像学改变、实验室资料及用药选择进行回顾性分析。结果　 12例患儿中 ,男 11例 ,女 1例。年龄 4～ 16岁 ,中位数年龄 10 5岁 ,其中 8岁以上 10例 (83% )。一级亲属中强直性脊柱炎 (AS) 1例 ,炎性下腰痛 3例。 9例存在附着点炎。 11例出现滑膜炎 ,主要为下肢大关节的非对称性少关节炎。 7例对骶髂关节进行了CT扫描 ,1例发现侵蚀样改变而构成幼年AS诊断。 10例有发热 ,1例起病前有腹泻史。 3例因合并尿道炎和漩涡状龟头炎而同时满足赖特综合征的诊断 ,其中 2例出现结膜炎 ,1例合并角膜炎。急性期普遍有炎症指标如白细胞、中性粒细胞、血小板、血沉、C反应蛋白、免疫球蛋白及补体C3 的增高。 4例有轻度贫血。 4例骨髓中见到组织细胞吞噬血细胞现象。 2例血中检测到细小病毒B19DNA ,1例血柯萨奇病毒IgM(+)。本组类风湿因子均为阴性 ,HLA B2 7均为阳性。非甾体抗炎药和柳氮磺吡啶是基本治疗药物。 3例因全身炎症反应剧烈而加用了肾上腺皮质激素作为“桥”治疗。 4例难治性或有髋关节受累者加用了氨甲喋呤 ,其中 2例还联 Objective To analyze the clinical features of adhering arthritis (ERA). Methods From February to November 2002, 12 patients with ERA were enrolled. All of them were in accordance with ILAR classification criteria of juvenile idiopathic arthritis (JIA) and ERA. The gender, age, family history, clinical manifestations, imaging changes, laboratory data and medication choices were retrospectively analyzed. Results 12 cases of children, 11 males and 1 female. Aged 4-16 years old, the median age of 10 5 years, of which 10 years old over 8 years (83%). First-degree relatives in ankylosing spondylitis (AS) in 1 case, inflammatory low back pain in 3 cases. Nine cases of attachment inflammation. 11 cases of synovitis, mainly for the lower extremity joint asymmetry less arthritis. 7 cases of sacroiliac joint CT scan, 1 case of erosion-like changes in the composition of juvenile AS diagnosis. Ten patients had fever, and one had a history of diarrhea before onset. Three cases were diagnosed with Wright’s syndrome due to urethritis and swollen balanitis, with 2 cases of conjunctivitis and 1 case of keratitis. Acute phase generally have inflammation indicators such as white blood cells, neutrophils, platelets, erythrocyte sedimentation rate, C-reactive protein, immunoglobulin and complement C3 increased. 4 patients had mild anemia. 4 cases of bone marrow to see the phenomenon of cells engulfing blood cells. Two cases of parvovirus B19DNA were detected in the blood and one case of blood coxsackievirus IgM (+). Rheumatoid factor in this group were negative, HLA B2 7 were positive. Non-steroidal anti-inflammatory drugs and sulfasalazine are the basic treatment drugs. 3 cases due to severe systemic inflammatory response plus the use of adrenal cortical hormone as a “bridge” treatment. Four patients with refractory or hip involvement were treated with methotrexate, and two of them were treated in combination