Purpose: According to Quigley’s hypothesis the dense of connective tissue is the least and the pores of the lamina cribrosa are the largest at the superior and inferior poles of the lamina cribrosa, therefore they are the most vulnerable location to be involved in the characteristic glaucomatous optic nerve damage. To get clinical evidence for the hypothesis, the reversal of optic cup in adults glaucoma after reduction of intraocular pressure (IOP) was examined.Methods: The stereoscopic flicker comparison on with computerized image system was used to monitor the optic cup’s changing, 2 serial superposed stereo pairs were displayed alternatively and rapidly and the changing parts appeared moving Under the stereoscopic observation, the changes of 3-dimention optic cup could be seen and the false positive phenomena caused by photographic angle variation, vascular pulsation could be differentiated from the characteristic change of the cup. Stereo fundus photographs were taken from 31 eyes with hypertension Purpose: According to Quigley’s hypothesis the dense of connective tissue is the least and the pores of the lamina cribrosa are the largest at the superior and inferior poles of the lamina cribrosa, therefore they are the most vulnerable location to be involved in the characteristic glaucomatous optic To get clinical evidence for the hypothesis, the reversal of optic cup in adults glaucoma after reduction of intraocular pressure (IOP) was examined. Methods: The stereoscopic flicker comparison on with computerized image system was used to monitor the optic cup’s changing, 2 serial superposed stereo pairs were displayed alternately and rapidly and the changing parts took moving Under the stereoscopic observation, the changes of 3-dimention optic cup could be seen and the false positive phenomena caused by photographic angle variation, vascular pulsation could be differentiated from the characteristic change of the cup. Stereo fundus were taken from 31 eyes with hypertension