前言对于职业毒害的慢性作用知识的发展及制訂接触毒物的安全标准的社会任务的增加,給毒理学研究带来許多新問題。測定不同染毒途径及染毒时間的LD_(50),已逐漸为寻找更敏感的反应指标所代替。当暴露后立即中毒,而且原发反应的后果支配整个临床表現时,鑑定有关的原发反应是相当容易的。例如一氧化碳与血紅蛋白的作用或氢氰酸 INTRODUCTION The development of knowledge about the chronic effects of occupational poisoning and the growing social task of developing safety standards for toxicant exposure have brought many new problems to toxicological research. Determination of different exposure routes and exposure time LD_ (50), has gradually replaced the search for more sensitive response indicators. When exposed to poison immediately, and the consequences of the primary reaction dominate the overall clinical picture, identifying the relevant primary reaction is fairly easy. For example, the role of carbon monoxide and hemoglobin or hydrocyanic acid