目的　研究缺血再灌注对于胎鼠小肠组织神经降压素 (NT)的影响 ,旨在探讨小肠组织NT含量的降低是否在坏死性小肠炎的发病机理中起着一定的作用。　方法　 5 7只胎鼠随机分为两组 ;假手术组 13只 ;缺血再灌注组 44只。缺血再灌注组再分为 组 34只 ,缺血时间分别为 5 min、10 min和 2 0 m in,再灌注组时间均为 5 min。再灌注 组 2 1只 ,缺血时间均为 10 min,再灌注时间分别为 5 min、2 0 m in。采用放射免疫的方法 ,检测 5 7只胎鼠小肠组织 NT的含量。　结果　缺血再灌注 组与假手术组相比 ,5 min时小肠组织 NT含量均有降低 ,分别为 (96± 7) ng/ mg与 (140± 12 ) ng/ mg,且随着缺血时间的延长 ,NT含量进一步下降 ,以缺血 10 m in、2 0 min降低最为明显 [2 0 m in时 NT 组为 (5 6±6 ) ng/ mg](P<0 .0 1)。缺血时间相同 ,随着再灌注时间的延长 ,小肠组织的 NT降低 ,再灌注 2 0 min与再灌注 5 m in比较差异有显著性 (P<0 .0 5 )。　结论　宫内缺血再灌注能造成胎鼠小肠组织 NT的降低。 Objective To investigate the effect of ischemia-reperfusion on neurotensin (NT) in small intestine of fetal rat and to investigate whether the reduction of NT content in small intestine plays a role in the pathogenesis of necrotizing enterocolitis. Methods A total of 57 fetuses were randomly divided into two groups: sham-operation group (n = 13) and ischemia-reperfusion group (n = 44). The ischemia-reperfusion group was further divided into 34 groups, the ischemia time was 5 min, 10 min and 20 min, and the reperfusion group time was 5 min. There were 21 reperfusion groups with ischemia for 10 min and reperfusion time of 5 min and 20 min respectively. Radioimmunoassay was used to detect the content of NT in 57 small fetuses. Results Compared with the sham operation group, the NT contents in the intestinal ischemia / reperfusion group were (96 ± 7) ng / mg and (140 ± 12) ng / mg, respectively, at 5 min, (P <0.01), and the NT content decreased further. The most obvious decrease was at 10 min of ischemia and 20 min of ischemia [(5 6 ± 6) ng / mg at 20 min] (P <0.01). The ischemia time was the same. With the prolongation of reperfusion time, the NT of small intestine decreased. There was a significant difference between reperfusion 20 min and reperfusion 5 min (P <0.05). Conclusion Intrauterine ischemia-reperfusion can reduce NT in fetal rat intestinal tissue.