目的通过测定原发性肝癌(HCC),肝动脉化疗栓塞术(TACE)与射频消融(RFA)治疗前后吲哚氰绿(ICG R15)及肝血清学指标,比较两种治疗方法对肝功能的损害。方法选取北华大学附属医院收治的HCC患者64例,分为TACE组(32例),RFA组(32例)。两组患者于术前及术后1周测定吲哚氰绿试验15min滞留率(indocyanine green retention rate at 15 min,ICG R15)和肝血清学指标。根据术前及术后上述指标的改变,评估并比较两组治疗方法对肝功能损害的程度。结果两种治疗方法均对肝功能造成损害,两组治疗后ICG R15均值都高于治疗前(P<0.05),TACE组治疗前后ICG R15均值的差值明显高于RFA组(P<0.05)。TACE组TB,ALT,γ-GT治疗前后的差值高于RFA组(P<0.05)。结论两种治疗方法对肝功能均造成一定损害,与TACE比较,RFA对肝功能的损害轻。 Objective To determine the changes of indocyanine green (ICG R15) and liver serology before and after treatment of primary hepatic carcinoma (HCC), transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) damage. Methods Totally 64 HCC patients admitted to Beihua University Affiliated Hospital were divided into TACE group (32 cases) and RFA group (32 cases). Two groups of patients were measured preoperatively and 1 week after the operation indocyanine green retention rate at 15 min (ICG R15) and liver serology indicators. According to preoperative and postoperative changes in the above indicators, assessment and comparison of two groups of treatment methods on the degree of damage to liver function. Results The two methods of treatment all had impaired liver function. The mean of ICG R15 in both groups after treatment was significantly higher than that before treatment (P <0.05). The difference of ICG R15 before and after treatment in TACE group was significantly higher than that in RFA group (P <0.05) . The difference between before and after treatment of TB, ALT and γ-GT in TACE group was higher than that in RFA group (P <0.05). Conclusion Both treatments have some damage to liver function. Compared with TACE, RFA has less damage to liver function.