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铍是一个有特殊理化性质的元素,故在科技,工业等领域有特殊用途。同时它也具有毒害作用所以在上世纪未就开始研究了铍的毒理性质。自1949年Klemper报导了铍抑制硷性磷酸酶后,许多人报导了,铍对某些其他酶亦有显著抑制作用。看来,铍是一种亲酶元素。与此同时许多人还发现,铍抑制的酶,有许多被镁离子所激活,并发现,铍与镁在对酶的作用上有竞争关系,即镁可以消除铍对酶的抑制。另一方面,一些事实也证明,铍中毒时出现免疫现象,因此认为铍中毒是变态反应的结果。这种观点是Иэраэль在1973年根据下例事实提出来的:1)有许多病例的气喘是刚接触氟化铍后就发生了。2)接触氟化铍的工人呼吸道疾患与熔炼车间工人一
Beryllium is a special physical and chemical properties of the elements, so in science and technology, industry and other fields have special uses. At the same time it also has the poisoning effect so in the last century did not begin to study the toxicological nature of beryllium. Since Klemper reported in beryllium inhibition of alkaline phosphatase in 1949, many reported that beryllium also has a significant inhibitory effect on certain other enzymes. It appears that beryllium is a type of enzyme that binds to enzymes. At the same time, many people also found that many of the beryllium-inhibited enzymes are activated by magnesium ions and found that beryllium and magnesium have a competitive relationship with the action of enzymes, that is, magnesium can eliminate the inhibitory effect of beryllium on the enzyme. On the other hand, some facts also prove that when beryllium poisoning occurs, so beryllium poisoning is considered as a result of allergy. This view is based on the fact that Иэраэль was introduced in 1973 on the basis of the following facts: 1) There are many cases of wheezing that occurred immediately after exposure to beryllium fluoride. 2) workers exposed to beryllium fluoride respiratory disorders and melting workshop workers one