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目的:了解食管癌家族聚集性的流行状况。方法:采用统一问卷调查表,逐户调查。对河南省食管癌高发区448户1107人进行家系调查。结果:共收回264份问卷。264户中,有家族性食管癌共153户(58%)。直系三代中发生10例以上食管癌患者的家庭有5户(2%),7例患者的家庭有8户(3%),而三代中发生6例、5例、4例和3例食管癌的家庭分别为13户(5%)、21户(8%)、28户(11%)和46户(17%)。结论:河南食管癌高发区食管癌家族聚集性发生十分常见,提示遗传因素在食管癌变中可能起重要作用。
Objective: To understand the prevalence of familial aggregation in esophageal cancer. Methods: Using a unified questionnaire, household survey. Henan province esophageal cancer incidence area 448 households 1107 people pedigree investigation. Results: A total of 264 questionnaires were returned. There were 153 households (58%) in 264 households with familial esophageal cancer. There were 5 households (2%) with 10 or more esophageal cancers in the immediate third generation, 8 (3%) in 7 patients, 6 in 3 generations, 5 in 4, and 3 in esophageal cancer Of the households are 13 (5%), 21 (8%), 28 (11%) and 46 (17%) respectively. Conclusion: The incidence of esophageal familial aggregation in Henan esophageal cancer is very common, suggesting that genetic factors may play an important role in esophageal carcinogenesis.