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用免疫组化ABC法，对87例原发性乳腺癌的手术标本经福尔马林固定、石蜡包埋、切片组织进行nm23－H1蛋白表达测定，分析其表达与淋巴结转移等指标的关系。结果：乳腺癌原发灶中nm23－H1表达阳性率为51·72％，区域淋巴结转移组阳性率为26％，无淋巴结转移组阳性率86．49％，差异非常显著（P＜0．001）。同时，随着乳腺癌核分裂的增多及病理学分级的增高，nm23－H1表达率下降，呈负相关趋势，nm23－H1表达在生存期≥5年及＜5年间及有无复发、脏器转移间差异显著（P＜0.001）。提示：测定乳腺癌组织中nm23－H1表达对判断转移和预后都有积极的临床意义。
Using immunohistochemical ABC method, surgical specimens of 87 cases of primary breast cancer were formalin-fixed, paraffin-embedded, and sectioned for nm23-H1 protein expression, and the relationship between their expression and lymph node metastasis was analyzed. Results: The positive rate of nm23-H1 expression in primary breast cancer was 51.72%, the positive rate in regional lymph node metastasis group was 26%, and the positive rate in no lymph node metastasis group was 86.49%. The difference was significant (P<0.001). ). At the same time, as the mitosis of breast cancer increases and the pathological grade increases, the expression rate of nm23-H1 decreases, showing a negative correlation trend. The expression of nm23-H1 has a survival period of ≥5 years and <5 years, and with or without recurrence and organ metastasis. The difference between the two groups was significant (P<0.001). Tip: The determination of nm23-H1 expression in breast cancer tissue has positive clinical significance in determining metastasis and prognosis.