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玉柏石松(Lycopodium obscurum L.)为石松科石松属植物,在我国作伸筋草入药,具有舒筋活血,祛风通络的作用,主治风湿性关节痛,四肢麻木,月经不调等症。前人曾从此植物中分得α-芒柄花萜醇(α-onocerin 1)。我们从玉柏石松中除分得1外,还分得两个四环三萜类化合物,经鉴定分别为26-失碳-8-氧代-α-芒柄花萜醇(26-nor-8-oxo-α-onocerin 2)和26,27-双失碳-8,14-二氧代-α-芒桐花萜醇(26,27-bisnor-8,14-dioxo-α-onocerin 3)。2为新化合物,3是首次从自然界分得。本文报道它们的化学结构。化合物1、2、3均为无色针晶,分子式分别为C_(30)H_(50)O_2(M~+442)、C_(29)H_(48)O_3(M~+444)和
Lycopodium obscurum L. is Lycopodium obescurum L., which belongs to the genus Lycopodium ostreatus in China. It is used as a medicinal herb in our country. It has the functions of relaxing muscle and promoting blood flow, expelling wind and meridians, indicating rheumatic joint pain, numbness of limbs, irregular menstruation and other symptoms. Previously, α-onocerin 1 was isolated from this plant. We divided 1 from P. cypress, and also obtained two tetracyclic triterpenoids, which were identified as 26-nor-carbon-8-oxo-α-canthallosterol (26-nor-8). -oxo-α-onocerin 2) and 26,27-destrone-8,14-dioxo-α-onocerin 3 (26,27-bisnor-8,14-dioxo-α-onocerin 3) . 2 is a new compound, and 3 is for the first time from nature. This article reports their chemical structure. Compounds 1, 2, and 3 are colorless needles with the molecular formula C 30 H 50 O 2 M 442 , C 29 H 48 O 3 M 444