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目的探讨环氧化酶-2(COX-2)在外阴硬化性苔癣(VLS)组织中的表达及意义。方法用免疫组化法检测COX-2在36例VLS组织及20例正常上皮组织中的表达。结果 COX-2在VLS组织和正常皮肤组织中的阳性表达率分别为77.8%(28/36)和0.00%(0/20),表达强度分别为(2.87±1.43)和(0.78±0.09),二者阳性表达率及表达强度差异均有统计学意义。结论 COX-2在外阴硬化性苔癣发生、发展中起一定作用。
Objective To investigate the expression and significance of cyclooxygenase-2 (COX-2) in vulvar lichen sclerosus (VLS) tissues. Methods Immunohistochemistry was used to detect the expression of COX-2 in 36 VLS tissues and 20 normal epithelial tissues. Results The positive expression rates of COX-2 in VLS tissues and normal skin tissues were 77.8% (28/36) and 0.00% (0/20), respectively. The expression intensity of COX-2 was (2.87 ± 1.43) and (0.78 ± 0.09) The positive rate of expression and the intensity of expression of the two were statistically significant. Conclusion COX-2 plays a role in the occurrence and development of vulvar lichen sclerosis.