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目的：探讨施他宁对门脉高压性胃病（ＰＨＧ）的治疗作用。方法：部分结扎大鼠门脉主干２周制作ＰＨＧ模型，观察施他宁对ＰＨＧ大鼠全身血流动力学、胃粘膜血流量（ＧＭＢＦ）、门脉压力（ＰＶＰ）和胃粘膜下层血管的影响，测定了输注施他宁３０ｍｉｎ后ＰＨＧ大鼠血浆胰高糖素，血浆和胃粘膜６－ｋｅｔｏ－ＰＧＦ１α含量，并与普萘洛尔进行了对比。结果：施他宁和普萘洛尔均能降低ＰＶＰ、ＧＭＢＦ，而对胃粘膜下层血管无影响；施他宁能拮抗ＰＨＧ大鼠胰高糖素作用、抑制胃酸和胃蛋白酶，对平均动脉压（ＭＡＰ）和心率无明显影响，普萘洛尔与施他宁相反；普萘洛尔和施他宁两组均不能拮抗ＰＧＩ２。结论：施他宁通过拮抗ＰＨＧ大鼠胰高糖素的作用降低ＧＭＢＦ，且对外周循环无明显影响
Objective: To investigate the therapeutic effect of sitotin on portal hypertensive gastropathy (PHG). Methods: PHG model was established by partial ligation of the main portal vein of rats for 2 weeks to observe the effects of systemic treatment on systemic hemodynamics, gastric mucosal blood flow (GMBF), portal pressure (PVP) and gastric submucosal blood vessels in PHG rats , The content of glucagon, plasma and gastric mucosa 6-keto-PGF1α in plasma of PHG rats after 30 min infusion of statin was measured and compared with that of propranolol. Results: Both strytine and propranolol decreased PVP and GMBF, but had no effect on gastric mucosa. Stathrine could antagonize the effect of glucagon in PHG rats, inhibit gastric acid and pepsin, (MAP) and heart rate, propranolol was the opposite of that of strytine; propranolol and shitatran both did not antagonize PGI2. Conclusion: Statonine reduces GMBF by antagonizing glucagon in PHG rats and has no significant effect on peripheral circulation