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对26例胶质瘤和18例颅内良性病变患者行18F-FDG和11C-MET PET/CT颅脑显像,定性和半定量分析两种显像图像。结果显示:11C-MET和18F-FDG PET/CT对胶质瘤诊断的准确率分别为88.6%和65.9%。半定量分析,26例胶质瘤11C-MET摄取值比值T/NGmax显著高于18F-FDG的T/NGmax(1.95±0.52 vs 0.90±0.27,t=9.101,P<0.001)。11C-MET和18F-FDG对高级别胶质瘤诊断的灵敏度无显著差异(100%vs.64.3%;χ2=3.20,P>0.05);对低级别胶质瘤诊断的灵敏度11C-MET(83.3%)高于18F-FDG(33.3%,χ2=4.16,P<0.05)。11C-MET显像高级别胶质瘤T/NGmax(2.07±0.51)与低级别胶质瘤(1.81±0.52)无显著差异(t=1.302,P=0.205);18F-FDG显像高级别胶质瘤T/NGmax(1.03±0.30)高于低级别胶质瘤(0.75±0.11,t=3.198,P=0.004)。表明11C-MET PET/CT显像对胶质瘤的诊断,特别是对低级别胶质瘤检出优于18F-FDG,两种显像综合应用有利于胶质瘤的准确分级。
18F-FDG and 11C-PET PET / CT brain imaging were performed in 26 gliomas and 18 patients with benign intracranial lesions. Both qualitative and semi-quantitative images were obtained. The results showed that the diagnostic accuracy of 11C-MET and 18F-FDG PET / CT for gliomas were 88.6% and 65.9%, respectively. Semiquantitative analysis showed that the ratio of T / NGmax of 11C-MET in 26 gliomas was significantly higher than that of 18F-FDG (1.95 ± 0.52 vs 0.90 ± 0.27, t = 9.101, P <0.001). The sensitivity of 11C-MET and 18F-FDG in the diagnosis of high-grade gliomas was no significant difference (100% vs.64.3%; χ2 = 3.20, P> 0.05) %) Higher than 18F-FDG (33.3%, χ2 = 4.16, P <0.05). There were no significant differences in T / NGmax (2.07 ± 0.51) and low grade gliomas (1.81 ± 0.52) between 11C-MET and high grade gliomas (t = 1.302, P = 0.205) T / NGmax of tumor (1.03 ± 0.30) was higher than that of low grade glioma (0.75 ± 0.11, t = 3.198, P = 0.004). It is indicated that 11C-MET PET / CT imaging is superior to 18F-FDG in the diagnosis of gliomas, especially in low-grade gliomas. The combined application of these two modalities is in favor of the accurate grading of gliomas.