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羰基镍为现代化学冶金工业生产中的一种剧毒化合物,研究表明动物染毒后在肺、肝、脑、肾等部位含镍量很高[1-2],其中急性肺损伤为羰基镍中毒后最突出的表现之一,而肺泡上皮细胞及肺毛细血管内皮细胞为主要受损靶点[3]。查阅文献至2012年全世界医学文献报道羰基镍中毒约数百例,但以急性呼吸窘迫综合征(ARDS)为主要表现的病例少见
Carbonyl nickel is a highly toxic compound in the production of modern chemical metallurgy industry. Studies have shown that the nickel content in lung, liver, brain, kidney and other parts of the animal after exposure to nickel is very high [1-2]. The acute lung injury is nickel carbonyl Poisoned after the most prominent manifestation of one of the alveolar epithelial cells and pulmonary capillary endothelial cells as the main target of damage [3]. Access to literature By 2012 medical literature around the world reported nickel carbonyl poisoning about 100 cases, but cases of acute respiratory distress syndrome (ARDS) as the main manifestation of rare