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前列腺疾病是较为常见的老年性疾病,在临床病理工作中,常常遇到前列腺良恶性病变的鉴别难题。前列腺特异性抗原不是前列腺癌的特异性标志物,前列腺酸性磷酸酶、前列腺抑肽素不能用于组织学诊断,p63是一种特异性和敏感性很高的新基底细胞标志物,而p504是新近发现的前列腺癌细胞标志物,具有较佳的敏感性,对鉴别前列腺良恶性病变有很大帮助。本文选取127例前列腺手术切除或穿刺标本进行p63和p504s免疫组化联合检测,以探讨其实用价值。
Prostate disease is a more common senile disease, in the clinicopathological work, often encountered the identification of benign and malignant prostatic lesions. Prostate-specific antigen is not a specific marker of prostate cancer, prostatic acid phosphatase, prostatitis can not be used for histological diagnosis, p63 is a new high specificity and sensitivity of basal cell markers, and p504 is Recently found prostate cancer cell markers, with better sensitivity, the identification of benign and malignant benign lesions of great help. This article selected 127 cases of prostate resection or puncture specimens p63 and p504s immunohistochemistry combined detection to explore its practical value.