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目的观察卡前列甲酯（ＰＧ０５）合并酪氨酰肼对小鼠抗早孕作用。方法小鼠于妊娠第７～９天给药，观察妊娠率；用放射免疫法测定血清孕酮水平。结果小鼠口服９０ｍｇ／ｋｇ酪氨酰肼（３ｄ）能显著增强皮下注射０．２ｍｇ／ｋｇＰＧ０５（２ｄ）的抗早孕作用，并协同ＰＧ０５降低孕小鼠血清孕酮的水平。３０μｇ／ｍｌ酪氨酰肼对大鼠黄体细胞３β－ＨＳＤ的活性有明显的抑制作用。口服１５０ｍｇ／ｋｇ酪氨酰肼（３ｄ）对假孕大鼠子宫孕激素受体数目无显著影响。结论酪氨酰肼抑制体内孕酮的生成可能是其协同ＰＧ０５抗早孕作用的主要机制。
Objective To observe the anti-early pregnancy effect of carbamazepine (PG05) combined with tyrosine hydrazide in mice. Methods The mice were administered on the 7th to 9th day of gestation and the pregnancy rate was observed. The serum progesterone level was measured by radioimmunoassay. Results Oral administration of 90 mg / kg tyrosine hydrazide (3d) significantly enhanced the anti-early pregnancy effect of subcutaneous injection of 0.2 mg / kg PG05 (2 d), and PG05 decreased the serum progesterone level in pregnant mice. 30μg / ml tyrosine hydrazide on rat luteal cells 3β-HSD activity was significantly inhibited. Oral administration of 150 mg / kg tyrosine hydrazide (3d) had no significant effect on the number of uterine progesterone receptors in pseudopregnant rats. Conclusion Tyrosin hydrazide inhibits the production of progesterone in vivo may be the main mechanism of its synergistic effect on PG05 anti-early pregnancy.