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目的探讨结直肠癌解剖部位与临床病理学特点间的关系。方法对 1 990～ 1 999年间收治的有完整临床资料的 790例结直肠癌进行回顾性分析。结果黏液腺癌在近、远端结肠癌、直肠癌中分别占 2 6 5 % (5 4 /2 0 4 )、1 0 1 % (1 5 /1 4 8)、9 4 % (36 /385 ) ;低分化癌在三个部位肿瘤中分别占 1 4 5 % (2 3/1 5 9)、5 7% (7/1 2 2 )、1 0 0 % (33/330 ) ;进展期癌 (DukesB期及B期以上 )分别占85 3% (1 6 8/1 97)、75 3% (1 1 3/1 5 0 )、77 1 % (2 96 /384 )。近端结肠癌同远端结肠癌或直肠癌相比差异均有显著性意义 (P <0 0 5 ) ;远端结肠癌同直肠癌相比 ,两者在分化程度上差异有显著性意义 (P <0 0 5 ) ,但在病理类型构成、肿瘤分期上无明显差异 (P >0 0 5 )。结论近端结肠癌具有明显不同于远端结肠癌或直肠癌的临床病理学特征 ,黏液腺癌更常见、分化更差、分期更晚 ,其预后可能更差
Objective To investigate the relationship between the anatomical location of colorectal cancer and clinicopathological features. Methods A retrospective analysis of 790 colorectal cancers with complete clinical data from 1990 to 1999 was conducted. Results Mucinous adenocarcinoma accounted for 26.5% (54/204), 100% (15/148), 94% (36/385) in proximal and distal colon cancer and rectal cancer, respectively ); Poorly differentiated cancer in the three parts of the tumor accounted for 115% (2 3/1 59), 57% (7/1 2 2), 100% (33/330); advanced cancer (DukesB and B above) accounted for 85 3% (1 6 8/1 97), 75 3% (1 1 3/1 5 0) and 77 1% (2 96/384), respectively. There was significant difference between proximal colon cancer and distal colon cancer or rectal cancer (P <0.05). Compared with rectal cancer, distal colon cancer showed significant difference (P <0.05) P <0.05), but there was no significant difference in the pathological type and tumor stage (P> 0.05). Conclusions Proximal colon cancer has clinically and pathologically distinct characteristics from distal colon or rectal cancer, with mucinous adenocarcinomas being more common, worse differentiated and later staging, and the prognosis may be worse