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【目的】 了解达纳康对新生儿窒息时机体红细胞免疫和过氧化物岐化酶 (SOD)的影响 ,寻找减轻新生儿窒息时脑损伤的有效药物。 【方法】 把 3 0例窒息新生儿随机分成治疗组和对照组。两组患儿均在窒息后第 1个 2 4h内抽第 1次血 ,治疗组患儿于第 1次抽血后即口服达纳康片剂 15mg/ (kg .d) ,分 2次 ,疗程 1周。对照组不给达纳康 ,其余治疗基本相同。 1周后 ,两组患儿均抽第 2次血。以E C3 bRR和E ICR作为评价红细胞免疫活性的指标 ,用放射免疫法测定SOD活性。 【结果】 窒息新生儿生后第 1天 ,治疗组与对照组的E C3 bRR、E ICR和SOD均无差异。 1周后 ,治疗组E C3 bRR为 (19.2 0± 4.2 1) % ,SOD为 (165 8.61± 3 62 .3 1) μg/L ,均显著高于对照组 (14 .87±4.99) % ,(13 2 4.83± 42 1.5 5 ) μg/L(P <0 .0 5 ) ;而治疗组E ICR为 (11.5 3± 4.18) %则显著低于对照组 (15 .40± 3 .0 2 ) % ,有统计学意义 (P <0 .0 5 )。 【结论】 达纳康清除自由基 ,减少脂质过氧化物的堆积。新生儿窒息时 ,应用达纳康对减轻脑细胞的不可逆损伤可能有一定意义
【Objective】 To investigate the effect of darunkang on the immune and superoxide dismutase (SOD) in neonates with asphyxia and to search for effective drugs to reduce the brain damage in neonatal asphyxia. 【Methods】 Thirty asphyxia neonates were randomly divided into treatment group and control group. The two groups of children were in the first 24 hours after asphyxiation pumping the first blood, the treatment group of children in the first blood after oral administration of danalcon tablet 15mg / (kg. D), 2 times, Treatment for 1 week. The control group did not give danacan, the rest of the treatment is basically the same. After 1 week, two groups of children were drawn the second blood. The E C3 bRR and E ICR were used as indexes to evaluate the erythrocyte immune activity, and SOD activity was determined by radioimmunoassay. 【Results】 There was no difference in E C3 bRR, E ICR and SOD between the treatment group and the control group on the first day after birth. After one week, the E C3 bRR of the treatment group was (19.2 ± 4.2 1)% and that of SOD was (165 8.61 ± 3 62.31) μg / L, which were significantly higher than that of the control group (14.87 ± 4.99)%, (13 2 4.83 ± 42 1.5 5) μg / L (P <0.05), while the E ICR in the treatment group was (11.5 3 ± 4.18)%, which was significantly lower than that in the control group (15 .40 ± 3.02) %, With statistical significance (P <0.05). 【Conclusion】 Danone can eliminate free radicals and reduce the accumulation of lipid peroxides. Neonatal asphyxia, the application of darnecan may reduce the irreversible damage of brain cells may have some significance