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本文报道国产头孢哌酮对临床分离的330株绿脓杆菌的体内、外抗菌作用情况。同时与头孢噻肟、头孢甲肟、哌拉西林、羧苄青霉素、丁胺卡那霉素和庆大霉素并用,对产生的协同作用进行比较。试验结果表明,头孢哌酮对绿脓杆菌的作用优于其它五种抗生素.在12.5微克/毫升浓度条件下,头孢哌酮可抑制80％的菌株。而对哌拉西林,庆大霉素,头孢噻肟,头孢甲肟和羧苄青霉素其抑制率分别为:75％,62％,13％,8％和0.9％。对小白鼠感染绿脓杆菌的体内试验结果表明:头孢哌酮的治疗效果高于头孢噻肟和羧苄青霉素。头孢哌酮分别与丁胺卡那霉素和庆大霉素所作的体外协同作用试验,以30株绿脓杆菌为例,试验结果表明协同作用显著,其FIC指数分别为0.5529和0.5406。
This article reports the domestic and foreign antibacterial effects of domestic cefoperazone on 330 clinically isolated Pseudomonas aeruginosa. In combination with cefotaxime, cefmenoxime, piperacillin, carbenicillin, amikacin, and gentamicin, the resulting synergistic effects were compared. The test results show that cefoperazone Pseudomonas aeruginosa effect is superior to the other five antibiotics at a concentration of 12.5 micrograms / ml, cefoperazone can inhibit 80% of the strains. The inhibitory rates of piperacillin, gentamicin, cefotaxime, cefmenoxime and carbenicillin were 75%, 62%, 13%, 8% and 0.9%, respectively. In vivo experiments on mice infected with Pseudomonas aeruginosa showed that cefoperazone was more effective than cefotaxime and carbenicillin. Cefoperazone, respectively, with amikacin and gentamicin in vitro synergy test to 30 Pseudomonas aeruginosa, for example, the test results show that the synergy, the FIC index was 0.5529 and 0.5406.