高脂血症被公认为导致动脉粥样硬化的主要危险因素之一，血管舒张功能异常与 之密切相关。由血管内皮细胞分泌的以一氧化氮为代表的内皮源性舒张因子产生和释放 减少，可能是导致内皮舒张功能减退的主要原因之一。本文主要综述了近年关于高脂血 症引起内皮舒张功能紊乱的可能机制，以及改善内皮功能的干预研究进展。 Hyperlipidemia is recognized as one of the major risk factors of atherosclerosis, and the abnormality of vasodilation is closely related to it. Decreased production and release of endothelium-derived relaxing factor, represented by nitric oxide, secreted by vascular endothelial cells may be one of the major causes of endothelial dysfunction. This review summarizes the possible mechanisms of endothelial dysfunction induced by hyperlipidemia in recent years and advances in interventions to improve endothelial function.