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目的:探讨虎参痛风丸的抗炎效果及亚急性毒性。方法:分别观察虎参痛风丸500,250,125mg·kg~(-1)虎参痛风丸组对二甲苯所致的小鼠耳肿胀、棉球致大鼠肉芽组织增生的影响。观察大剂量长期用药对大鼠的影响。结果:虎参痛风丸能显著抑制二甲苯所致的小鼠耳肿胀,抑制棉球所致的大鼠肉芽组织的增生;亚急性毒性实验表明虎参痛风丸无明显毒性,血清丙氨酸氨基转移酶(GPT)与对照组比较无显著性差异。结论:虎参痛风丸有明显的抗炎作用且无明显的毒性。
Objective: To investigate the anti-inflammatory effect and subacute toxicity of Hushen Tongfeng Pill. Methods: The effects of 500, 250, 125 mg·kg -1 of Hushen Tongfeng Pills and Hushentongfeng Pills on the swelling of mouse ears induced by xylene and the proliferation of rat granulation tissue induced by cotton balls were observed. Observe the effect of large doses of long-term medication on rats. RESULTS: Hushen Tongfeng Pill can significantly inhibit xylene-induced mouse ear swelling and inhibit the proliferation of granulation tissue in rats induced by cotton balls. Subacute toxicity test showed that Hushen Tongfeng Pill had no obvious toxicity, serum alanine amino GPT was not significantly different from the control group. Conclusion: Hushen Tongfeng Pill has obvious anti-inflammatory effect and no obvious toxicity.