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目的观察米非司酮胶囊(Ⅱ)对子宫内膜异位症的疗效。方法 30例子宫内膜异位症患者,于月经周期第1天开始服米非司酮胶囊(Ⅱ)5 mg,1次/d,连续服用6个月观察临床疗效及生殖激素的改变。结果服药期间所有患者均闭经,痛经及盆腔痛消失或减轻,腺肌症患者子宫明显缩小、卵巢异位囊肿缩小或消失。雌二醇(E2)及孕酮(P)处于早~中卵泡期水平。结论米非司酮胶囊(Ⅱ)长期服用可破坏子宫内膜的完整性,干扰其功能,影响在位及异位内膜的生物学效应,从而起到治疗子宫内膜异位症的作用。尤其适用于围绝经期及卵巢子宫内膜异位囊肿的治疗。
Objective To observe the curative effect of mifepristone capsule (Ⅱ) on endometriosis. Methods Thirty patients with endometriosis started taking mifepristone capsules (Ⅱ) 5 mg once daily for 6 months on the first day of the menstrual cycle to observe the changes of clinical efficacy and reproductive hormones. Results All patients underwent amenorrhea, dysmenorrhea and pelvic pain disappeared or reduced during treatment. The uterus of adenomyosis patients was significantly reduced and the ovarian ectopic cyst was reduced or disappeared. Estradiol (E2) and progesterone (P) in early ~ middle follicular phase level. Conclusion Long-term use of mifepristone capsules (Ⅱ) can destroy the integrity of the endometrium, interfere with its function and affect the biological effects of the eutopic and ectopic endometrium, thus playing a role in the treatment of endometriosis. Especially for perimenopausal and ovarian endometriosis cyst treatment.