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目的:探讨危重病患者血浆内皮素(ET)的变化及其与β—内啡肽(β—EP)两者的关系。方法:用放射免疫分析法对43例危重病患者(脑血管意外12例,心力衰竭15例和创伤16例)及19名健康人ET与β—EP进行测定,并对二者的相关性进行分析。结果:心力衰竭患者血浆ET含量明显升高,与对照组比较有显著性差异(P<0.01);脑血管意外患者血浆β—EP水平显著升高,与对照组比较差异非常显著(P<0.001)。心力衰竭者血浆ET与β—EP的浓度呈负相关(r=-0.459,P<0.05)。结论:危重病心力衰竭患者血浆ET水平异常增高,脑血管意外者血浆β—EP含量显著升高,二者的变化可能在上述疾病发生发展进程中有重要意义。关于二者在疾病发生中是否有因果关系,有待进一步深入研究。
Objective: To investigate the changes of plasma endothelin (ET) and its relationship with β-endorphin (β-EP) in critically ill patients. Methods: 43 critically ill patients (12 cases of cerebrovascular accident, 15 cases of heart failure and 16 cases of trauma) and ET and β-EP of 19 healthy people were determined by radioimmunoassay. The correlation between the two analysis. Results: The content of plasma ET in patients with heart failure was significantly higher than that in the control group (P <0.01). The level of plasma β-EP in patients with cerebrovascular accident was significantly higher than that in the control group (P <0.001) ). Plasma ET was negatively correlated with β-EP in patients with congestive heart failure (r = -0.459, P <0.05). Conclusion: The level of ET in patients with critically ill heart failure is abnormally elevated, while the level of plasma β-EP in patients with cerebrovascular accident is significantly increased. The changes of both may play an important role in the development of these diseases. Whether there is a causal relationship between the two in the occurrence of the disease remains to be further studied.