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亚德里亚霉素(ADM)和阿克拉霉素(ACM)是蒽环类的抗肿瘤抗生素。ADM在实验肿瘤和临床使用的研究中都证明具有抗肿瘤谱广、活性强的优点,已由上海医药工业研究院合成成功,不久将供应临床使用。ACM被认为是第二代的蒽环类新的抗肿瘤抗生素,含有A、B两种组分。国外对A组份的药效、毒性和作用机制作了大量研究,目前已进入Ⅲ期临床试验。四川抗菌素工业研究所于1979年在四川思文找到了产生阿克拉霉素的菌株,并经发酵提取分离得到A和B的纯品。本文以形态法、扫描电镜超微形态及[~3H]-TdR前体掺入的半微量实验操作方法观察了国产 ADM、ACM-A、ACM-B对人体舌鳞状细胞系Tca8113的药敏反应。
Adriamycin (ADM) and aclacinomycin (ACM) are anthracycline antitumor antibiotics. ADM in the experimental tumor and clinical studies have shown that with broad anti-tumor spectrum, the advantages of strong activity, has been successfully synthesized by the Shanghai Institute of Pharmaceutical Industry, will soon supply clinical use. ACM is considered as the second generation anthracycline antitumor antibiotics, containing A, B two components. A large number of foreign studies on the pharmacodynamics, toxicity and mechanism of component A, has now entered the phase Ⅲ clinical trials. Sichuan Institute of Antibiotics in 1979 found in Sijin Sichuan aclacinomycin-producing strains, and the fermentation extract isolated A and B of the pure. In this paper, we observed the drug sensitivity of domestic ADM, ACM-A and ACM-B to the human tongue squamous cell line Tca8113 by means of morphological methods, SEM micrographs and [~ 3H] -TdR incorporation. reaction.