洛伐他汀是一类羟甲基戊二酰辅酶A(HMG-CoA)还原酶抑制剂,能够有效降低胆固醇及低密度脂蛋白含量,是治疗心血管疾病、代谢综合征等严重威胁人类健康的疾病的有效药物。围绕洛伐他汀的发酵合成,人们进行了众多研究,包括发酵基本参数优化、代谢调控、固态发酵研究等,使洛伐他汀的产量得到很大提升。 Lovastatin is a class of hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, can effectively reduce the cholesterol and low density lipoprotein content, is the treatment of cardiovascular diseases, metabolic syndrome and other serious threats to human health Effective drug for the disease. Many studies have been carried out on the synthesis of lovastatin, including optimization of basic parameters of fermentation, metabolism regulation, solid state fermentation, etc., so that the yield of lovastatin is greatly improved.