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本文报道4例并发尿崩症的急性非淋巴细胞白血病(ANLL),其骨髓细胞染色体检查均显示7号单体(-7或7q-)异常。患者年龄50～60岁,男女各半,均患 M_2型 ANLL和尿崩症(DI)。DI 的诊断依据为:多饮、多尿(每日>6L),尿比重和尿渗透压低,禁水试验示尿液不能浓缩。当鼻腔给予去氨加压素(desmopressin)后,尿量及尿比重发生显著改变,证实其 DI 为中枢性而非肾性。4例具有共同的血液学特点。即在发生 ANLL前均有骨髓增生异常综合征(MDS)的细胞学改变,
This paper reports 4 cases of acute non-lymphocytic leukemia (ANLL) complicated by diabetes insipidus. All chromosomes of bone marrow cells showed the abnormalities of 7 (7 or 7q-). Patients aged 50 to 60 years old, male and female half, are suffering from M_2 ANLL and diabetes insipidus (DI). DI diagnosis based on: polydipsia, polyuria (daily> 6L), urinary specific gravity and urine osmolality, water test showed that urine can not be concentrated. After nasal administration of desmopressin, there was a significant change in urine output and urine specific gravity, confirming that DI was central rather than renal. Four patients had common hematological features. That before the occurrence of ANLL have myelodysplastic syndrome (MDS) cytology,