由于钙拮抗剂对房室传导有抑制作用,故异搏定、硫氮酮已用于防治室上性心动过速和控制心房纤颤(房颤),通常与地高辛联用。已有报道异搏定、硝苯吡啶等钙拮抗剂可使血清地高辛浓度增高,但地高辛与硫氮酮的相互影响尚无报道。为此,作者对地高辛与硫氮酮以及β-甲基地高辛与硫氮酮的相互影响进行研究。因为β-甲基地高辛几乎完全被 Because of calcium antagonists on atrioventricular conduction inhibition, so verapamil, diltiazem has been used to prevent supraventricular tachycardia and control of atrial fibrillation (atrial fibrillation), usually combined with digoxin. It has been reported that verapamil, nifedipine and other calcium antagonists can increase the concentration of serum digoxin, but the interaction between digoxin and diltiazem has not been reported. To this end, the authors studied the interaction between digoxin and diltiazem and β-methyl digoxin and diltiazem. Because beta-methyl digoxin almost completely