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目的:对疑似非淋菌性尿道炎(NGU)患者衣原体、支原体感染分析,并检测其对抗菌药物敏感情况,为临床用药提供参考。方法:选择2015年3月-2016年3月于宁波市第四医院治疗疑似支原体感染患者600例,经衣原体试剂盒定性检测衣原体抗原、支原体培养及药敏试验,并分析9种抗生素对支原体敏感性。结果:600例疑似NGU感染患者中,288例检出各种病原体感染,阳性率48.0%,Ct阳性率为9.5%,支原体阳性率为38.5%;NGU感染患者的活跃人群主要集中在20~30岁及31~40岁年龄段,发病率为70.49%;女性患者Ct、Uu及Ct+Uu感染阳性率分别为52.6%、40.5%、6.0%均显著高于男性患者,差异具有统计学意义,P<0.05;142株支原体对9抗生素均存在不同程度耐药,且检出多重耐药菌株。耐药率最高的为环丙沙星,其次为红霉素、左旋氧氟氟沙星;敏感率较高的为美满霉素、强力霉素、克拉霉素。结论:NGU患者支原体感染主要为Uu,且女性检出率较高。根据药敏结果,首选抗菌药物为美满霉素、强力霉素或克拉霉素。
Objective: To analyze the infection of chlamydia and mycoplasma in patients with suspected non-gonococcal urethritis (NGU), and to test its sensitivity to antibiotics, so as to provide reference for clinical use. Methods: From March 2015 to March 2016, 600 patients suspected of mycoplasma infection were treated in the Fourth Hospital of Ningbo City. Chlamydia pneumoniae, mycoplasma and drug susceptibility tests were qualitatively detected by the Chlamydia pneumoniae kit. Nine antibiotics were also tested for their susceptibility to Mycoplasma Sex. Results: Of the 600 patients suspected of having NGU infection, 288 cases detected various pathogen infections, the positive rate was 48.0%, the positive rate of Ct was 9.5%, and the positive rate of mycoplasma was 38.5%. The active population of NGU infection was mainly 20-30 The prevalence rates of Ct, Uu and Ct + Uu in female patients were 52.6%, 40.5% and 6.0%, respectively, which were significantly higher than those in male patients, the difference was statistically significant, P <0.05; 142 strains of Mycoplasma 9 antibiotics exist in varying degrees of resistance, and the detection of multi-drug resistant strains. Ciprofloxacin with the highest resistance rates was followed by erythromycin and levofloxacin, and the highest sensitivity rates were minocycline, doxycycline and clarithromycin. Conclusion: Mycoplasma infection in NGU patients is mainly Uu, and the detection rate of women is higher. According to drug susceptibility results, the preferred antibacterial drug for minocycline, doxycycline or clarithromycin.