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目的探讨炎性因子以及PCT对于鉴别诊断颅内感染的性质的临床价值。方法选取我院收治的30例化脓性脑膜炎患者作为A组,选取27例病毒性脑炎患者作为B组,另选取18例正常人群作为C组,比较各组脑脊液IL-6、IL-8以及血清PCT的浓度变化情况。结果3组患者的IL-6、IL-8以及TNF-ɑ比较差异有统计学意义(P<0.05),A组PCT水平明显高于C组及B组,差异有统计学意义(P<0.05),C组及B组之间PCT水平比较差异无统计学意义(P>0.05)。A组以及B组治疗后的脑脊液IL-6、IL-8以及TNF-ɑ水平均明显低于治疗前,A组治疗后的PCT水平明显下降,差异有统计学意义(P<0.05),B组患者治疗前后的PCT水平比较差异无统计学意义(P>0.05)。结论脑脊液IL-6、IL-8以及TNF-ɑ、PCT水平对于颅内感染的病情监测以及疗效评价等方面均有着十分重要的价值。
Objective To investigate the clinical value of inflammatory cytokines and PCT in the differential diagnosis of intracranial infection. Methods Thirty patients with purulent meningitis treated in our hospital were selected as group A, 27 patients with viral encephalitis were selected as group B, and 18 normal subjects were selected as group C. The levels of IL-6, IL-8 As well as the concentration of serum PCT changes. Results The levels of IL-6, IL-8 and TNF-ɑ in the three groups were significantly different (P <0.05). The PCT level in group A was significantly higher than that in group C and group B (P <0.05 ). There was no significant difference in PCT level between group C and group B (P> 0.05). The levels of IL-6, IL-8 and TNF-Î’in cerebrospinal fluid in group A and group B after treatment were significantly lower than those before treatment. The PCT levels in group A were significantly decreased after treatment (P <0.05), and B There was no significant difference in PCT levels between before and after treatment in the group of patients (P> 0.05). Conclusion The levels of IL-6, IL-8, TNF-ɑ and PCT in cerebrospinal fluid are of great value in monitoring the condition of intracranial infection and evaluating the curative effect.