从中药知母提得有效成分知母皂甙(简称 ZMS),经动物实验证明对肾细胞的 Na~+,K~+,ATP 酶(钠泵)有明显的抑制作用,在离体兔心房其正性肌力作用为心脏钠泵抑制剂哇巴因的1/660,而毒性则为后者的1/192。近有报道,肝癌病人的代谢紊乱,主要由于瘤细胞的钠泵活性的增高,并已将知母作为“清热泻火药”试治肝癌病人。本工作进行知母皂甙的健康志愿者试验,为其代替粗制剂试用于临床提供临床药理 From the traditional Chinese medicine Anemarrhena active ingredients timosaponins (referred to as ZMS), animal experiments proved that renal cells Na ~ +, K ~ +, ATPase (sodium pump) had a significant inhibitory effect in isolated rabbit atrial Introphy is 1/60 of ouabain, a cardiac sodium pump inhibitor, and 1/192 toxic to the latter. It has been recently reported that patients with liver cancer metabolic disorders, mainly due to tumor cells increased sodium pump activity, and has Anemarrhena as “heat purging powder ” test treatment of liver cancer patients. In this work, we conducted a trial of healthy volunteers with timosaponins to provide clinical pharmacology instead of crude preparations