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目的 :研究恒定、低剂量微粒化 1 7β雌二醇 (诺坤复 )在赠卵助孕术中的应用。方法 :1 999年 1月至 2 0 0 0年 7月 ,应用诺坤复 1～ 2 mg/ d和黄体酮为 43例接受赠卵的患者准备子宫内膜共 5 1个周期 ,由 40例同期行体外受精和胚胎移植 (IVF-ET)或配子输卵管内移植术 (GIFT)的不孕患者和 5名正常妇女提供卵母细胞。结果 :供卵和接受赠卵者共移植 90个周期 ,妊娠 34例 ,妊娠率为 38%。接受赠卵的 5 1个周期中 ,临床妊娠 2 0例 ,供卵者移植 39例中 ,临床妊娠 1 4例 ,妊娠率分别为 39%和 36 % ,两组间无显著差别 ,妊娠与未妊娠患者之间平均年龄、不孕原因和移植的胚胎数等均无显著差别。结论 :在等待赠卵期间 ,用低剂量 (1～ 2 mg/ d)诺坤复可有效地刺激子宫内膜生长 ,为胚胎移植作准备。
OBJECTIVE: To study the application of constant, low-dose micronized 17β-estradiol in donated egg pregnancy. METHODS: From January 1999 to July 2000, 51 cases of endometrium were treated with norvofibrate 1 ~ 2 mg / day and progesterone for 43 cases, Infertility patients and 5 normal women who underwent in vitro fertilization and embryo transfer (IVF-ET) or gametocyte intragluality transplantation (GIFT) provided oocytes. Results: A total of 90 cycles of donor and recipient donors, pregnancy 34 cases, the pregnancy rate was 38%. In 51 cycle of receiving donated eggs, 20 cases of clinical pregnancy, 39 cases of ovarian transplantation, clinical pregnancy 14 cases, the pregnancy rates were 39% and 36%, no significant difference between the two groups, pregnancy and not The mean age between pregnancies, the causes of infertility and the number of embryos transferred did not differ significantly. Conclusion: During the waiting period of ovulation, low dosage (1 ~ 2 mg / d) Norcoxon can effectively stimulate the growth of endometrium and prepare for embryo transfer.