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1996年Pilia等克隆到了过度生长综合征(Simpson-Golabi-Behmel syndrome,SGBS)患者Xq26区的磷脂酰肌醇蛋白聚糖-3基因(Glypican-3,GPC3)。GPC3在细胞的生长发育中起着重要的调控作用,正是由于该基因的突变导致了SGBS。最近还发现该基因与几种恶性肿瘤的发生有关。文章就该基因与生长调控及肿瘤的研究进展作一综述。
In 1996, Pilia et al cloned glypican-3 (Glypican-3, GPC3) in Xq26 region of patients with Simpson-Golabi-Behmel syndrome (SGBS). GPC3 plays an important regulatory role in cell growth and development, which is due to the mutation of SGBS. Recently also found that the gene is associated with the occurrence of several malignancies. The article reviews the gene and its regulation of growth and tumor progression.