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在驱除肠道线虫药物中,有的因毒性大或疗效差已被淘汰,有的因副反应大或疗效不理想已无法广泛应用.为此,本文仅就当前常用的驱除肠道线虫新药作简要介绍,以供医务工作者参考. 噻嘧啶(Pyrantel pamoate) 本药全称为双萘羟酸噻嘧啶,商品名“抗虫灵”、“疳病痊”(其枸橼酸盐即“驱虫灵”),现已普遍推广使用.国内外均证明本药驱除钩虫、蛔虫和蛲虫效果良好,副反应轻,病人耐受性好,没有致畸性,有利于群众性治疗。药理:本病是去极化神经肌肉阻断剂,能使蠕虫产生痉挛性麻痹,停止活动,安全排出。口服后60～94％由粪便排出,1～3％由尿排出。
In eradicating intestinal nematodes drugs, some because of toxicity or poor efficacy has been eliminated, and some due to side effects or efficacy is not ideal has been widely used.Therefore, this article only on the current commonly used to eradicate intestinal nematodes new drugs A brief introduction for medical workers.Pyrantel pamoate The full name of this medicine is pyranipirol dinaphthalene, the trade name “insect-resistant spirit”, “hysteria” (the citrate that is “deworming Spirit ”), is now widely used at home and abroad have proved that the drug get rid of hookworm, roundworm and pinworm good effect, side effects, patient tolerance, no teratogenicity, is conducive to mass treatment. Pharmacology: The disease is to de-polarization neuromuscular blockers, can make worms spastic paralysis, stop activities, safe discharge. After oral administration of 60 to 94% excreted by the feces, 1 to 3% from the urine.