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近年来,中等剂量和大剂量阿糖胞苷(Ara-C)治疗急、慢性白血病已逐渐流行。这种增强治疗已发现有许多副作用,包括严重的骨髓抑制、粘膜炎和中枢神经系统毒性。急性或亚急性非心源性肺水肿在最近也被承认为该疗法的副作用。作者对103例复发的白血病患者采用大剂量Ara-C治疗,每次在2小时内静注3g/m~2,6～1.2小时一次,总计9～12次;或在2小时内静
In recent years, moderate and high doses of cytarabine (Ara-C) treatment of acute and chronic leukemia has become increasingly popular. This intensive treatment has been found to have many side effects, including severe myelosuppression, mucositis and central nervous system toxicity. Acute or subacute non-cardiogenic pulmonary edema has also recently been recognized as a side effect of this therapy. The authors of 103 cases of relapsed leukemia patients with high-dose Ara-C treatment, each intravenous infusion of 3g / m ~ 2 ~ 2 ~ 1.2 hours within 2 hours, a total of 9 to 12 times; or within 2 hours of static